dose of applied nanomaterial internalised by a specific cell population (or per single cell) - particle number / cell area
Correlation of dose and response for nanomaterials toxicity assessment requires information on the amount of the applied dose of nanomaterial that has been internalised by a cell population (or per specific cell) and is dependent on a number of factors including the exposure time, the particle density (i.e., whether settling occurs and thus the distribution of particles in the medium is non-homogeneous affecting the local concentration at the cell surface) etc.
- Property
- number per area
- Object of Interest
- nanomaterial particle Constraint(s)
- entering the cell
- Matrix
- cell surface